Infective endocarditis (IE) is a lethal infection even in the era of antibiotic therapy and cardiovascular surgery. The clinical course of IE varies from an uncomplicated infection with minor valve damage to a fulminant life-threatening condition. Although immunological phenomena are present in IE there is no clinical evidence on the use of immunomodulatory therapies. Is immunomodulation beneficial or harmful in IE? We present a case of a successful outcome of a patient with IE to whom corticosteroids were given along with antimicrobial treatment.